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Review Question - QID 104439

QID 104439 (Type "104439" in App Search)
A 5-year-old boy presents to the emergency department with a sore throat and trouble breathing. His mother states that his symptoms started last night and have rapidly been worsening. The patient is typically healthy, has received all his childhood immunizations, and currently takes a daily multivitamin. His temperature is 103°F (39.4°C), blood pressure is 100/64 mmHg, pulse is 155/min, respirations are 29/min, and oxygen saturation is 95% on room air. Physical exam is notable for an ill-appearing child who is drooling and is leaning forward to breathe. He does not answer questions and appears very uncomfortable. He will not comply with physical exam to open his mouth for inspection of the oropharynx. Which of the following is the most likely infectious etiology of this patient's symptoms?

Candidia albicans

4%

4/112

Epstein-Barr virus

22%

25/112

Haemophilus influenzae

14%

16/112

Streptococcus pneumoniae

57%

64/112

Streptococcus viridans

1%

1/112

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This patient is presenting with a high fever, dysphagia, drooling, and respiratory distress which is concerning for a diagnosis of epiglottitis. In vaccinated patients, Streptococcus pneumoniae is a common etiology of epiglottitis.

Epiglottitis has a rapid onset (1-3 hours) and presents with a high fever, dysphagia, drooling, and stridor. Historically, the most common infectious etiology was Haemophilus influenzae; however, in the setting of modern vaccinations other more common causes include Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus. The management of this condition is immediate intubation in the operating room as any possible perturbation of the patient's airway could lead to airway loss. Antibiotics that could be appropriate include ceftriaxone, cefotaxime, and cefuroxime.

Incorrect Answers:
Answer 1: Candidia albicans can cause epiglottitis but usually this would only occur in a very ill and immunocompromised patient.

Answer 2: Epstein-Barr virus can cause infectious mononucleosis which presents with fatigue, malaise, splenomegaly, posterior cervical lymphadenopathy, and tonsillar exudates. It would not cause epiglottitis.

Answer 3: Haemophilus influenzae is the most common cause of epiglottitis in unvaccinated patients; however, it is a more rare cause (though still possible) in vaccinated patients.

Answer 5: Streptococcus viridans is normal flora in the mouth and could cause bacterial endocarditis after a dental procedure in a patient with an abnormal or mechanical valve.

Bullet Summary:
Common causes of epiglottitis in vaccinated patients include Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus.

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