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Review Question - QID 104277

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QID 104277 (Type "104277" in App Search)
A 64-year-old man presents for a routine physical. He states that he has felt abnormally weak during this time and has had trouble focusing in the setting of losing 5 pounds. The patient states he has a decreased appetite and also has not had a bowel movement in the past 5 days and feels uncomfortable. On review of system, he endorses abdominal pain. His temperature is 97.5°F (36.4°C), blood pressure is 132/83 mmHg, pulse is 115/min, respirations are 15/min, and oxygen saturation is 98% on room air. Physical exam is notable only for the patient being able to recall 1 of 3 objects. His cranial nerve exam is unremarkable and his gait is stable. Urinalysis is initially notable for a clear and voluminous sample with a low specific gravity. Which of the following tests is most likely abnormal in this patient?

Calcium level

23%

13/57

Lead level

11%

6/57

Phosphate level

4%

2/57

Potassium level

51%

29/57

TSH level

11%

6/57

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This patient is presenting with confusion, constipation, and increased urination which is likely caused by hypercalcemia (possibly from malignancy or hyperparathyroidism though more diagnostic testing would be needed).

Clinical symptoms associated with hypercalcemia include fractures, nephrolithiasis, vomiting, constipation, and altered mental status. These symptoms are typically summarized as "bones (fractures and pain), stones (nephrolithiasis), groans (vomiting and constipation), and psychic overtones (altered mental status)." There are many possible etiologies of hypercalcemia including malignancy, familial hypocalciuric hypercalcemia, and hyperparathyroidism. The treatment of hypercalcemia is first to give IV fluids. Subsequent treatments can include calcitonin and bisphosphonates (for long-term management). The underlying etiology should be elucidated and treated as well.

Incorrect Answers:
Answer 2: Lead level could be used to elucidate a diagnosis of lead poisoning which may present with confusion, constipation, and irritability in an adult. This is a less common diagnosis (without a key exposure such as working in a battery factory) and would not explain this patient's dilute urine.

Answer 3: Phosphate level could elucidate a diagnosis of hypophosphatemia which may occur in refeeding syndrome or hyperparathyroidism and presents with weakness, muscle/bone pain, confusion, and possibly rhabdomyolysis.

Answer 4: Potassium level could work up a diagnosis of hyperkalemia which could cause peaked T waves and QRS widening on ECG that could lead to cardiac arrest. Hypokalemia can also present with non-specific changes on physical exam including weakness.

Answer 5: TSH level could elucidate a diagnosis of hypothyroidism which would present with depression, fatigue, weight gain, and constipation. Though there is significant overlap with hypercalcemia, this patient's dilute urine and weight loss suggest hypercalcemia as a more likely etiology.

Bullet Summary:
Hypercalcemia can present with confusion, abdominal pain, constipation, and profuse urination.

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