Snapshot A 35-year-old man presents to his primary care physician for numbness and weakness of the left lower extremity and "cold-like" symptoms. He has also noticed skin changes in the affected leg. His medical history is significant for asthma treated with albuterol. Physical exam is significant for 3/5 strength throughout the lower extremity and decreased touch sensation. There are cutaneous and subcutaneous nodules. Laboratory findings are significant for positive MPO-ANCA/p-ANCA antibodies and a serum eosinophil level of 8000/μL. Introduction Definition login to view 4 more bullets Epidemiology Demographics login to view 2 more bullets ETIOLOGY Pathogenesis login to view 1 more bullet Presentation Symptoms/physical exam login to view 11 more bullets Other findings login to view 2 more bullets Studies Labs login to view 3 more bullets Differential Granulomatosis with polyangiitis login to view 3 more bullets Temporal arteritis login to view 3 more bullets Treatment Medical login to view 3 more bullets Complications Necrotizing glomerulonephritis Purpura Parenchymal disease Prognosis Improved with immunosuppressive treatment