Updated: 11/19/2017

Recombinant Cytokines

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  • A 66-year-old man presents to his primary care physician due to worsening shortness of breath, fatigue, and edema. Medical history is significant for type II diabetes mellitus and chronic kidney disease with his last eGFR reading at 85 mL/min/1.73 m2. He has yet to need dialysis. Laboratory testing is significant for a hemoglobin of 9.0 g/dL and an eGFR of 55 mL/min/1.73 m2. After further evaluation of non-renal causes of anemia, it was determined that erythropoietin should be added to his treatment regimen to improve his symptoms.
Introduction
 
Immunosuppressants
Medication
Mechanism of Action Clinical Use
Aldesleukin
  • IL-2 product which leads to proliferation, differentiation, and recruitment of T-, B-cell, and NK cells
  • Metastatic renal cell carcinoma
  • Metastatic melanoma
Erythropoietin (epoetin alfa)
  • Stimulates erythroid progenitor cells to divide and differentiate
  • Anemia
Filgrastim
  • Granulocyte colony stimulating factor which results in neutrophil proliferation, differentiation, and activation
  • Recovery of leukocyte count and bone marrow
Sargramostim
  • Granulocyte macrophage colony stimulating factor which results in neutrophil and monocyte proliferation, differentiation, and activation
IFN-α
  • Multiple effects
  • Chronic hepatitis B and C
  • Malignant melanoma
  • Condyloma acuminatum
  • Hairy cell leukemia
  • Kaposi sarcoma
IFN-β
  • Multiple sclerosis
IFN-γ
  • Chronic granulomatous disease
Romiplostim (thrombopoietin)
  • A thrombopoietin (TPO) analog that acts on the TPO receptor to ↑ platelet count
  • Thrombocytopenia
Eltrombopag
  • A TPO agonist that leads to ↑ platelet count
  • Thrombocytopenia
Oprelvekin (IL-11) 
  • A thrombopoietic growth factor that results in ↑ platelet count
  • Thrombocytopenia
 
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