Snapshot A 40-year-old East Asian man presents for painful oral and genital ulcers. He reports that he has had these ulcers for about a week. About a year ago, he moved from Malaysia to the United States. He reports that he is currently not sexually active and has had a test for HIV half a year ago, which was negative. He is in a 3-year monogamous relationship. Physical exam shows 3 aphthous ulcers in his oral mucosa. Genital exam reveals multiple erythematous ulcers along his penis. Additionally, there are soft subcutaneous nodules along his bilateral shins. Labs reveal increased inflammatory markers. He is given topical corticosteroids. Introduction Clinical definition login to view 1 more bullet Epidemiology Incidence login to view 1 more bullet Demographics login to view 2 more bullets Risk factors login to view 2 more bullets etiology Pathogenesis login to view 2 more bullets Associated conditions login to view 1 more bullet Presentation Symptoms login to view 3 more bullets Physical exam login to view 14 more bullets Imaging Magnetic resonance imaging (MRI) of head login to view 2 more bullets Computed tomography (CT) of chest login to view 2 more bullets Studies Labs login to view 5 more bullets Biopsy login to view 6 more bullets Differential Herpes genitalis Syphilis Inflammatory bowel disease DIAGNOSIS Making the diagnosis login to view 1 more bullet Treatment Management approach login to view 1 more bullet Medical login to view 16 more bullets Complications Blindness from ocular disease Thrombosis