Snapshot A 60-year-old man presents to his physician’s office for fatigue, dry mouth, and dry eyes for the past year. He reports having always had a history of dry eyes that is managed with artificial tears. A year ago, he started feeling thirsty and was evaluated for diabetes, which was ruled out. He reports that he had several dental caries at his last dental appointment, despite maintaining overall good oral hygiene habits. Physical exam reveals bilateral swollen parotid glands, conjunctivitis, and dry mucous membranes. He also has dental caries. He is sent for additional workup for suspicion of an autoimmune disease. Introduction Clinical definition login to view 1 more bullet Epidemiology Prevalence login to view 1 more bullet Demographics login to view 3 more bullets Risk factors login to view 2 more bullets ETIOLOGY Pathogenesis login to view 5 more bullets Associated conditions login to view 10 more bullets Presentation Symptoms login to view 10 more bullets Physical exam login to view 12 more bullets Imaging Salivary gland scintigraphy or contrast sialography login to view 2 more bullets Studies Labs login to view 5 more bullets Corneal staining to assess ocular damage Labial salivary gland biopsy login to view 4 more bullets Differential Diabetes Hepatitis C Anticholinergic drug use Mumps DIAGNOSIS Making the diagnosis login to view 1 more bullet Treatment Medical login to view 10 more bullets Complications Dental caries Oral candidiasis Corneal abrasion or ulceration Mucosa-associated lymphoid tissue lymphoma Parotid gland infection Prognosis Patients are at risk for non-Hodgkin lymphoma and other autoimmune diseases