Septic embolism is an obstruction of a blood vessel, typically by an infected thrombus that travels through the bloodstream from a distant infectious source and blocks a blood vessel. Septic emboli result in two insults—the early embolic/ischemic insult due to vascular occlusion that may lead to infarction and the infectious insult that leads to inflammation and possible abscess formation.[1] Septic embolism frequently results from infective endocarditis. In fact, Osler nodes (the tender purplish-colored papules), which are pathognomonic of infective endocarditis, are indeed evidence of embolism, a biopsy of which results in the isolation of respective causative microorganisms.[2]