The definition of anemia is a low hemoglobin level than the normal range for each age group. Generally, anemia classifies into three categories based on the mean corpuscular volume (MCV) of red blood cells. Iron deficiency anemia is the most common type of anemia worldwide in all age groups. However, here we talk about a rare type of anemia with genetic etiology. Diamond Blackfan anemia (DBA) is a congenital type of anemia characterized by pure red cell aplasia and associated with congenital bone abnormalities. It is a chronic macrocytic-normocytic anemia. DBA is a heterogeneous genetic disease inherited as an autosomal dominant inheritance in 40 to 45% of cases. The remainder, 55 to 60% of cases, typically present sporadically. There are also cases noted with autosomal recessive inheritance with less frequency.  Hydrops may occur but very rarely.