While typically thought of as a disease in neonates, gonococcal conjunctivitis (GC) is an infectious process that has also become an increasing issue in other age groups. When it occurs in neonates, GC is also known as gonococcal ophthalmia neonatorum and is most likely due to maternal transmission during birth. In older age groups, GC is more associated with sexually transmitted infections (STIs) but can also present without evidence of concomitant genital infection. The condition is important to recognize as untreated cases can lead to significant life-threatening like meningitis and/or altering consequences for patients, for example, blindness.