• OBJECTIVE
    • To describe the clinical features of ethambutol neuroretinopathy.
  • DESIGN
    • Case report and meta-analysis of the literature.
  • PARTICIPANTS
    • A patient with clinical and electrophysiological findings suggestive of ethambutol neuroretinopathy.
  • TESTING
    • Electroretinogram, electro-oculogram and visual fields.
  • MAIN OUTCOME MEASURE
    • Clinical and electrophysiological findings.
  • RESULTS
    • 101 cases were reviewed, retinal findings include retinal pigment epithelial changes, macular edema, flame-shaped hemorrhages. Electroretinogram findings include decreased amplitude and abnormal wave pattern in full field ERG, multifocal or pattern ERG and electro-oculogram findings include abnormal Arden ratio.
  • CONCLUSIONS
    • Clinical, electrophysiological and in vitro studies support the toxic effect of ethambutol on the retina. Therefore ethambutol ocular toxicity may be a neuroretinopathy.