Snapshot A 37-year-old woman with uveitis on prednisone (20 mg daily) presents to her primary care provider due to weight gain. Since establishing her treatment for uveitis, she reports significant improvement in her vision with the resolution of the flare. However, over the couple of months, she has also noticed menstrual irregularities, abnormal hair growth on her face, and skin changes. She reports eating a well-balanced diet and although she has been trying to engage in an exercise program, she has been feeling very weak and unable to do so. Introduction Clinical definition login to view 1 more bullet Epidemiology Most common cause of Cushing syndrome is iatrogenic Etiology Pathogenesis login to view 6 more bullets Presentation Symptoms login to view 6 more bullets Physical exam login to view 8 more bullets Studies Diagnostic testing login to view 18 more bullets Diagnostic criteria login to view 11 more bullets Differential Pseudo-Cushing syndrome login to view 2 more bullets Cushing disease login to view 3 more bullets Non-iatrogenic Cushing syndrome login to view 5 more bullets Treatment Management approach login to view 4 more bullets Complications Opportunistic fungal infections Perforated viscera Adrenal crisis Osteoporosis