Snapshot A 65-year-old woman with a past medical history significant for type 2 diabetes, glaucoma, and psoriasis presents to the emergency room for altered mental status. For the past few days, she has had increasing cough followed by polyuria, weakness, and fatigue. She has had a few tactile fevers at home. On physical exam, she is febrile and tachycardic. Her skin turgor is poor and she has dry mucous membranes. She is alert and oriented only to self, a change from her baseline. Laboratory results are significant for an elevated serum glucose of 730 mg/dL. Arterial blood gas shows a normal pH. No ketones are detected in the serum. Chest radiograph shows a new right lower lobe infiltrate. She is given a bolus of fluids and admitted to the intensive care unit for further management. Introduction Clinical definition login to view 6 more bullets Associated conditions login to view 1 more bullet Epidemiology Demographics login to view 3 more bullets etiology Medication noncompliance Acute medical illness login to view 4 more bullets Pathogenesis login to view 6 more bullets Presentation Symptoms login to view 10 more bullets Studies Diagnostic testing login to view 7 more bullets Differential Diabetic ketoacidosis login to view 4 more bullets DIAGNOSIS Diagnostic criteria login to view 1 more bullet Treatment Management approach login to view 1 more bullet First-line login to view 6 more bullets Complications Thrombosis