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  • A 45-year-old obese woman is seeking weight loss options. She has tried multiple diet plans without much effect. Although she considered gastric bypass surgery, she is worried about the complications of surgery as her mother died after an abdominal surgery. She had heard a commercial about a miracle weight loss drug and asks her primary care physician about her options. Her doctor warns her that while this medication can induce weight loss, it can also have other side effects such as defecation urgency and abdominal pain.
Orlistat
  • Mechanism of action
    • reversibly inhibits pancreatic lipase, causing decreased breakdown and absorption of fats
    • causes a caloric deficit
  • Clinical use
    • obesity
    • weight loss
  • Adverse effects
    • gastrointestinal upset
    • flatulence
    • frequent bowel movements
    • defecation urgency
    • anal discharge
    • fat-soluble vitamin deficiencies
Lorcaserin
  • Mechanism of action
    • selective serotonin receptor agonist (5-HT(2C) agonist)
      • results in decreased food intake via increasing sensation of satiety
  • Clinical use
    • obesity
      • in the presence of weight-related comorbidity
  • Adverse effects
    • gastrointestinal upset
    • dizziness
    • pharyngitis
    • fatigue

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