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Updated: Jul 1 2024

Obstetric Medications

  • Obstetrics Drug Introduction
    • Obstetrics medications can be broken down into the following categories
      • diabetic agents
      • hormone agonists
      • hormone antagonists
  • Endocrine Drug Table
    • Obstetric Medications
        • Inducers
        • Name
        • Mechanism of Action
        • Key Indication
        • Key Toxicity
        • Oxytocin
        • Acts via IP3 pathway 
        •  Also has weak ADH properties
        • Labor induction
        •  Uterine bleeding
        •  Breastfeeding
        • Hyponatremia
        •  Increased heart rate
        •  Decreased blood pressure
        • Misoprostol (PGE1)
        • Cervical ripening
        •  Increases GI mucous production
        • Labor induction
        •  Abortion
        •  Ulcers
        • GI disturbance
        • Dinoprostone (PGE2)
        • Increases uteirne tone
        • Labor induction
        •  Cervical ripening
        • GI disturbance
        •  Fever
        • Headache
        • Tocolytics
        • Name
        • Mechanism of Action
        • Key Indication
        • Key Toxicity
        • Terbutaline
        • β2 agonist
        • Tocolysis:
        • indication
        • 24-32 weeks
        • indomethacin (first-line)
        • nifedipine (second-line)
        • 32-34 weeks
        • nifedipine (first-line)
        • terbutaline (second-line)
        •  Close PDA (indomethacin)
        • Sympathetic symptoms (anxiety, tachycardia etc.)
        •  Hyperglycemia
        • Indomethacin
        • COX 1/2 inhibitor (NSAID)
        • Tocolysis:
        • indication
        • 24-32 weeks
        • indomethacin (first-line)
        • nifedipine (second-line)
        • 32-34 weeks
        • nifedipine (first-line)
        • terbutaline (second-line)
        • Close PDA (indomethacin)
        • Drowsiness
        •  Dizziness
        •  Ulcers
        • Nifedipine
        • Calcium channel blocker
        • Tocolysis:
        • indication
        • 24-32 weeks
        • indomethacin (first-line)
        • nifedipine (second-line)
        • 32-34 weeks
        • nifedipine (first-line)
        • terbutaline (second-line)
        • Close PDA (indomethacin)
        • Nausea
        •  Flushing
        •  Headaches
        • Magnesium sulfate
        • NMDA modulation
        • thought to compete with calcium
        • Pre-eclampsia
        •  Eclampsia (seizures)
        •  Torsades
        •  Bronchodilation
        • Depressed deep tendon reflexes
        •  Drowsiness
        •  Cardiac arrest
        •  Respiratory depression
    • Gynecologic Medications
        • Estrogens
        • Name
        • Mechanism of Action
        • Key Indication
        • Key Toxicity
        • Estradiol
        • Estrogen receptor agonist
        • Hormone contraception
        •  Hormone replacement therapy
        • Breast cancer
        •  Endometrial cancer
        •  Ovarian cancer
        • Menstrual Cycle Regulators
        • Name
        • Mechanism of Action
        • Key Indication
        • Key Toxicity
        • Clomiphene citrate
        • Estrogen receptor antagonist (particularly in the hypothalamus → increase GnRH)
        • Fertility
        •  Ovulation induction
        • Ovarian enlargement
        •  Visual symptoms
        •  Headaches
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