Updated: 3/26/2020

Antivirals

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Antivirals
 
Blocks Viral Attachment, Penetration, or Uncoating
 Name of Drug Key Indication(s)
Key Toxicity
Prevents Viral Uncoating
Amantadine
  • Influenza A
  • Livedo reticularis
  • Ataxia
Rimantadine
Fusion Inhibitors
Enfurvirtide
  • HIV
  • Skin reaction
Maraviroc
Viral DNA Polymerase Inhibitors
Acyclovir
  • HSV
  • VZV
  • EBV
  • Crystalline nephropathy that can lead to acute renal failure 
Valacyclovir
Famiciclovir
Ganciclovir
  • CMV
  • Neutropenia
  • Leukopenia
  • Thrombocytopenia
  • Renal toxicity
Foscarnet
  • Second-line drug for CMV and HSV
  • Seizures
  • Nephrotoxicity
  • Electrolyte abnormalities
Cidofovir
  • Nephrotoxicity
Viral RNA Polymerase Inhibitors
Ribavirin
  • Chronic hepatitis C
  • RSV
  • Viral hemorrhagic fevers
  • Bone marrow suppression
  • Teratogenic
Reverse Transcriptase Inhibitors (RTIs)
Nucleoside RTIs
Zidovudine
  • HAART (HIV)
  • Bone marrow suppression
  • Neuropathy
  • Lactic acidosis
  • Anemia (zidovudine)
  • Pancreatitis (didanosine)
Didanosine
Zalcitabine
Lamivudine
Stavudine
Non-Nucleoside RTIs
Nevirapine
  • HAART (HIV)
  • Rash
  • Hepatotoxicity
  • Dysphoric dreams (efavirenz)
Efavirenz
Protease Inhibitors
Saquinavir
  • HAART (HIV)
  • Hyperglycemia
  • Hyperlipidemia
  • Lipodystrophy
  • GI intolerance
  • Hematuria (indinavir)
  • Nephropathy (indinavir)
Ritonavir
Indinavir
Nelfinavir
Amprenavir
Blocks Viral Release
Oseltamivir
  • Influenza A and B
  • Flu-like syndrome
  • Nausea
  • Vomiting
Zanamivir

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