Antivirals Blocks Viral Attachment, Penetration, or Uncoating Prevents Viral Uncoating Name of Drug Key Indication(s) Key Toxicity Amantadine Rimantadine Influenza A Livedo reticularis Ataxia Fusion Inhibitors Name of Drug Key Indication(s) Key Toxicity Enfurvirtide Maraviroc HIV Skin reaction Viral DNA Polymerase Inhibitors Name of Drug Key Indication(s) Key Toxicity Acyclovir Valacyclovir Famiciclovir HSV VZV EBV Crystalline nephropathy that can lead to acute renal failure Ganciclovir CMV Neutropenia Leukopenia Thrombocytopenia Renal toxicity Foscarnet Second-line drug for CMV and HSV Seizures Nephrotoxicity Electrolyte abnormalities Cidofovir Second-line drug for CMV and HSV Nephrotoxicity Viral RNA Polymerase Inhibitors Name of Drug Key Indication(s) Key Toxicity Ribavirin Chronic hepatitis C RSV Viral hemorrhagic fevers Bone marrow suppression Teratogenic Reverse Transcriptase Inhibitors (RTIs) Nucleoside RTIs Name of Drug Key Indication(s) Key Toxicity Zidovudine Didanosine Zalcitabine Lamivudine Stavudine HAART (HIV) Bone marrow suppression Neuropathy Lactic acidosis Anemia (zidovudine) Pancreatitis (didanosine) Non-Nucleoside RTIs Name of Drug Key Indication(s) Key Toxicity Nevirapine Efavirenz HAART (HIV) Rash Hepatotoxicity Dysphoric dreams (efavirenz) Protease Inhibitors Name of Drug Key Indication(s) Key Toxicity Saquinavir Ritonavir Indinavir Nelfinavir Amprenavir HAART (HIV) Hyperglycemia Hyperlipidemia Lipodystrophy GI intolerance Hematuria (indinavir) Nephropathy (indinavir) Blocks Viral Release Name of Drug Key Indication(s) Key Toxicity Oseltamivir Zanamivir Influenza A and B Flu-like Syndrome Nausea Vomiting