Please confirm topic selection

Are you sure you want to trigger topic in your Anconeus AI algorithm?

Updated: Jun 9 2022

Antibiotics

5.0

  • star icon star icon star icon
  • star icon star icon star icon
  • star icon star icon star icon
  • star icon star icon star icon
  • star icon star icon star icon

(6)

  • Classification & Indications
    • Cell Wall Synthesis Inhibitors
        • Penicillins
        • (Bactericidal: inhibits bacterial cell wall synthesis via competitive inhibition of the transpeptidase enzyme)
        • Class
        • Name of Drug(s)
        • Key Indications(s)
        • Penicillin 
        • Penicillin G
        • Aqueous (crystalline) penicillin G
        • Procaine penicillin G
        • Benzathine penicillin G
        • Penicillin V
        • S. pnuemoniae
        • S. pyogenes (group A strep)
        • N. meningitidis
        • T. pallidum
        • L. monocytogenes
        • A. israelii
        • P. multocida
        • Aminopenicillins
        • Ampicillin
        • Amoxicillin
        • ↑ gram-negative coverage
        • Enterococci (group D strep)
        • All others listed above
        • Penicillinase-resistant penicillins
        • Methicillin
        • Nafcillin
        • Oxacillin
        • Cloxacillin
        • Dicloxacillin
        • Penicillinase-producing S. aureus
        • All others listed above
        • Antipseudomonal penicillins
        • Carbenicillin
        • Ticarcillin
        • Piperacillin
        • P. aeruginosa
        • Anaerobic bacteria
        • All others listed above
        • Cephalosporins
        • (Bactericidal: inhibits bacterial cell wall synthesis via competitive inhibition of the transpeptidase enzyme)
        • Class
        • Name of Drug(s)
        • Key Indication(s)
        • 1st generation 
        • Cefazolin
        •  Cephalexin
        • Gram-positives
        •  Some gram-negatives
        •  Skin infection prophylaxis
        • 2nd generation
        • Cefoxitin
        •  Cefaclor
        •  Cefuroxime
        • Gram-positives
        •  Improved gram-negative coverage
        •  Anaerobes
        • 3rd generation
        • Ceftriaxone
        •  Cefotaxime
        •  Ceftazidime
        • Serious gram-negative infections
        • Meningitis
        • Pseudomonas
        • 4th generation
        • Cefepime
        • Same coverage as cephalosporins +
        • expanded Pseudomonas coverage + 
        • expanded gram-positive coverage
        • 5th generation
        • Ceftaroline
        • Expanded gram-positive and gram-
        • negative coverage, non-suitable coverage of Pseudomonas
        • Other Cell Wall Inhibitors
        • Class
        • Name of Drug(s)
        • Key Indications(s)
        • Vancomycin
        • Vancomycin
        • MRSA
        •  Patients with PCN or ceph allergies
        •  S aureus
        •  S epidermidis
        •  C. difficile
        • Beta-lactamase inhibitors
        • Clavulanic acid
        •  Sulbactam
        •  Tazobactam
        • Gram-positive
        •  S. aureus
        •  S. epidermis
        •  Gram-negative
        •  E. coliKlebsiella
        • Carbapenems

        • Broadest activity of any antibiotic (does NOT cover MRSA, Mycoplasma, and some Pseudomonas)
        • Aztreonam
        • Aztreonam
        • Gram-negative rods
        • Aerobes
        • Difficult-to-treat hospital-acquired infections
        • Polymyxins
        • Polymyxin B
        •  Polymyxin E
        • Topical gram-negative infections
        • Bacitracin
        • Bacitracin
        • Topical gram-positive infections
    • Protein Synthesis Inhibitors
        • Anti-30S Ribosomal Subunit
        • Class
        • Name of Drug(s)
        • Key Indications(s)
        • Aminoglycosides
        • (bactericidal)
        • Gentamicin
        • Neomycin
        • Amikacin
        • Tobramycin
        • Streptomycin
        •  Severe gram-negative infections
        • Aerobes only
        • Can lead to nephrotoxicity and ototoxicity
        • Tetracyclines
        • (bacteriostatic)
        • Tetracycline
        • Doxycycline
        • Minocycline
        • Demeclocycline
        • Chlamydia
        • Rickettsia
        • Bacteria without peptidoglycan cell walls
        • Spirochetes
        • V. cholerae
        • H. pylori
        • Anti-50S Ribosomal Subunit
        • Class
        • Name of Drug(s)
        • Key Indications(s)
        • Macrolides
        • Erythromycin
        • Azithromycin
        • Clarithromycin
        • Outpatient URI, LRI
        • Atypical pneumonia
        • STDs
        • Gram-positive cocci
        • Chloramphenicol   
        • (bacteriostatic)
        • Chloramphenicol
        • H. influenzae
        • Bacterial meningitis
        • Brain abscess
        • Bacteroides fragilis
        • Clindamycin 
        • (bacteriostatic)
        • Clindamycin
        • Anaerobes above the diaphragm
        • Female GU
        • TSS  
        • Linezolid
        • (variable)
        • Linezolid
        • Resistant gram-positives (MRSA, VRE)
        • Streptogramins
        • Quinupristin
        • Dalfopristin
        • VRE
        • GAS and S. aureus skin infections
        • Note: bacteriocidal when used together
    • DNA Synthesis Inhibitors
        • Fluoroquinolones
        • (Bactericidal: inhibit DNA gyrase enzyme, inhibiting DNA synthesis)
        • Class
        • Name of Drug(s)
        • Key Indications(s)
        • 1st generation
        • 4th generation
        • Gram-negative UTIs
        • 2nd generation
        • Ciprofloxacin
        • Norfloxacin
        • Enoxacin
        • Ofloxacin
        • Levofloxacin
        • Gram-negative UTIs
        • Gram-negative GI tract
        • Pseudomonas
        • 3rd generation
        •  Gatifloxacin
        • As above + gram-positives
        • 4th generation
        • Moxifloxacin
        • Gemifloxacin
        • As above + gram-positives + anaerobes
        • Other DNA Inhibitors
        • Class
        • Name of Drug(s)
        • Key Indications(s)
        • Metronidazole
        • (bacteridical: metabolic byproducts disrupt DNA)
        • Metronidazole (Flagyl)
        • Bacteria AND protozoa
        • Anaerobes below the diaphragm
        • C. difficile
        • H. pylori
    • RNA Synthesis Inhibitors
        • Class
        • Name of Drug(s)
        • Key Indications(s)
        • Rifampin   
        • (bactericidal: inhibits RNA transcription)
        •  Rifampin
        • TB
        • Leprosy
        • H.influenzae prophylaxis
        • Antistaphylococcal
    • Mycolic Acids Synthesis Inhibitors
        • Class
        • Name of Drug(s)
        • Key Indications(s)
        • Isoniazid
        • Isoniazid
        • Latent TB
        • Can cause peripheral neuropathy
        • Elevated liver enzymes most common side effect of RIPE therapy
    • Folic Acid Synthesis Inhibitors
        • Class
        • Name of Drug(s)
        • Key Indications(s)
        • Sulfonamides
        • Sulfamethoxazole (SMX)
        • Sulfisoxazole
        • Sulfadiazine
        • Respiratory (S. pneumoniae, H. influenzae)
        • GI (enterics)
        • UTIs
        • PCP and T. gondii
        • Trimethoprim
        • Trimethoprim
        •  Sulfonamides
        • Pyrimethamine
        • Pyrimethamine
        • Malaria
        • T. gondii
    • Miscellaneous   
        • Drugs
        • Mechanism of Action
        • Indications and Side Effects
        • Pyrazinamide
        • Uncertain mechanism: potentially accumulates in cells disrupting membrane potential and fatty acid synthesis
        • Part of RIPE therapy for TB
        •  Can cause hyperuricemia and hepatoxicity
        • Ethambutol
        • Inhibits arabinosyltransferase (inhibiting production of mycobacterium cell wall)
        • Part of RIPE therapy for TB and used for M. avium-intracellulare
        •  Can cause optic neuropathy (red-green color blindness)
        • Daptomycin
        • Lipopeptide that disrupts cell membrane
        • Multi-resistant gram-positives such as MRSA and VRE
        •  Can cause myopathy (elevated CK and rhabdomyolysis
Card
1 of 0
Question
1 of 2
Private Note

Attach Treatment Poll
Treatment poll is required to gain more useful feedback from members.
Please enter Question Text
Please enter at least 2 unique options
Please enter at least 2 unique options
Please enter at least 2 unique options