Snapshot A 28-year-old G3P2 female at 39 weeks of gestation is on the labor and delivery floor in active labor. The cervix is 10 centimeters dilated and preparations are made for delivery of the newborn. A male neonate is born with appropriate Apgar scores and without any perinatal complications. During placental delivery there is a lot of resistance when traction is placed on the umbilical cord. After an attempt at manual placental separation, there is profuse bleeding. Obstetric history is significant for previous cesarean delivery. She has missed a number of prenatal visits during this pregnancy. Introduction Overview abnormal implantation of the placenta chorionic villi of the placenta attach to the surface of the myometrium rather than the decidua Epidemiology Incidence 0.17% prevalence of any placental abnormality during pregnancy placenta accreta most common 63% of all placental abnormalities Risk factors placenta previa (low-lying placenta that covers cervix) after prior C-section history of uterine surgery advanced maternal age multiparity history of manual removal of placenta infertility procedures ETIOLOGY Pathogenesis Theory of defective decidualization thin, poorly formed, partial, absent or dysfunctional decidua in an area of scarring from previous uterine surgery that involved the endometrial-myometrial interface allows for placental villi to attach directly to (or invade as in placenta percreta/increta) myometrium Classification Placenta accreta spectrum placenta accreta placental villi attach to myometrium (instead of decidua) placenta increta placental villi penetrate into the myometrium placenta percreta placental villi penetrate through the myometrium and attach to the uterine serosa or adjacent organs Presentation Symptoms often asymptomatic profuse life-threatening hemorrhage during attempted manual placental separation Physical Exam inability to fully separate placenta from uterus after delivery Imaging Transvaginal or transabdominal ultrasonography indications routine prenatal care a history of cesarean delivery or other uterine surgeries used for diagnosis antenatally findings second and third trimester low anterior placenta multiple irregularly shaped placental lacunae placental lacunae are vascular spaces “moth-eaten” appearance of placenta myometrial thinning placental bulge disruption of bladder line retroplacental space is disrupted or lost Studies Histology placental villi attached to the myometrium in the absence of a decidual plate used for diagnosis postnatally Maternal serum alpha-fetoprotein abnormally elevated in second trimester Differential Placenta increta Placenta percreta key distinguishing factors ultrasound findings placental vessels extending through myometrium into bladder or other serosa a focal mass breaking through uterine serosa and extending into bladder Complications Massive hemorrhage Death Prognosis 27% morbidity worse with placenta percreta Risk of death from sequelae of massive hemorrhage